Comparison of cerebrospinal fluid biomarkers of Alzheimer's disease with commercial kits

Cerebrospinal Fluid Biomarkers for Huntington's Disease.

Cerebrospinal fluid (CSF) is enriched in brain-derived components and represents an accessible and appealing means of interrogating the CNS milieu to study neurodegenerative diseases and identify biomarkers to facilitate the development of novel therapeutics. Many such CSF biomarkers have been proposed for Huntington's disease (HD) but none has been validated for clinical trial use. Across many...

Medical Policy Cerebrospinal Fluid and Urinary Biomarkers of Alzheimer Disease

Cerebrospinal fluid biomarkers in the evaluation of Alzheimer disease.

Alzheimer disease (AD), the most prevalent form of dementia in older adults, is a neurodegenerative disorder characterized by cerebral amyloid angiopathy, extracellular accumulation of amyloid -protein (A ) in senile plaques, and intracellular accumulation of hyperphosphorylated proteins in neurofibrillary tangles in cortical and limbic brain regions. As life expectancy increases, the number of...

Longitudinal Measurements of Cerebrospinal Fluid Biomarkers in Parkinson's Disease

OBJECTIVE The purpose of this study was to investigate whether cerebrospinal fluid (CSF) levels of tau, phosphorylated tau, β-amyloid42 , α-synuclein, neurofilament light, and YKL-40 change over time and if changes correlate with motor progression and/or cognitive decline in patients with PD and controls. METHODS We included 63 patients with PD (nondemented) and 21 neurologically healthy cont...

Multiple Sclerosis Cerebrospinal Fluid Biomarkers

Cerebrospinal fluid (CSF) is the body fluid closest to the pathology of multiple sclerosis (MS). For many candidate biomarkers CSF is the only fluid that can be investigated. Several factors need to be standardized when sampling CSF for biomarker research: time/volume of CSF collection, sample processing/storage, and the temporal relationship of sampling to clinical or MRI markers of disease ac...